Former "Friends" co-star David Schwimmer's directing debut, the comedy "Run, Fat Boy, Run," was a dud, taking in $2.4 million to finish out of the top 10. Released by Picturehouse, the movie stars Simon Pegg as an out-of-shape slacker running a marathon to impress his former fiance, played by Thandie Newton.

The audience for "21" was split almost evenly between men and women and those older and younger than 25, according to Sony.

"One of the coolest things is it really did play to everyone. It got male, female, young, old," said Rory Bruer, Sony's head of distribution.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Media By Numbers LLC.

1. "21," $23.7 million.

2. "Dr. Seuss' Horton Hears a Who!", $17.4 million.

3. "Superhero Movie," $9.5 million.

4. "Tyler Perry's Meet the Browns," $7.8 million.

5. "Drillbit Taylor," $5.8 million.

6. "Shutter," $5.3 million.

7. "10,000 B.C.", $4.9 million.

8. "Stop-Loss," $4.5 million.

9. "College Road Trip," $3.5 million.

10. "The Bank Job," $2.8 million.